Ronidazole Capsules
Ronidazole
60mg/150mg
Capsules
Oral durg for eliminate trichomoniasis infection used in animals only
Description:
Ronidazole is supplied as capsules containing 60mg/150 mg Ronidazole per capsule . Ronidazole is a carbamate ester that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by methyl and (carbamoyloxy)methyl groups, respectively. An antiprotozoal agent, it is used in veterinary medicine for the treatment of histomoniasis and swine dysentery. It has a role as an antiprotozoal drug and an antiparasitic agent. It is a member of imidazoles, a carbamate ester and a C-nitro compound.The chemical name of Ronidazole is C6H8N4O4,the ctural formula of Ronidazole is:
Indications:
Ronidazole is indicated for titrichomonas foetus Infections in Cats, itrichomonas foetus Infections in other animals. Ronidazole is the only antimicrobial for which convincing efficacy for treatment of feline Tritrichomonas species infection has been demonstrated. Most cats with Tritrichomonas species infection show significant improvement in fecal consistency, or resolution of diarrhea, during the course of treatment with Ronidazole.
Dosage and Administration:
The typical dosage for cats is in the range of 30-50mg/kg,once daily. It is often around 14 days, Ronidazole is commonly administered with food to minimize potential gastrointestinal side effects.
Contraindications:
Ronidazole should not be given in pregnancy and lactation, neurological conditions, l iver dysfunction, hypersensitivity or allergies.
Warnings:
User Safety Warnings: Not for use in humans. Keep this and all medications out of reach of children. Consult a physician in case of accidental ingestion by humans.
Animal Safety Warnings: Keep Ronidazole in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.
Owners should wear gloves when administering Ronidazole and when cleaning up the litter box during treatment and for 3 days after treatment is completed.
Give this medication to your pet as directed by your veterinarian.
Ronidazole is a potentially mutagenic, carcinogenic, and embryo-toxic substance in humans when they are exposed to it over long periods of time. Short term exposure during a typical 14 day course of treatment is not thought to pose significant risks to either the pet or its owner Feces should be double bagged and then disposed of in the regular trash. This should be continued for 3 days after the treatment is finished. Pregnant women should not handle Ronidazole.
Adverse Reactions:
Neurological Effects: Ronidazole can affect the nervous system, and signs may include:disorientation,incoordination,head tilting,tremors,seizures.
Gastrointestinal Distress: Some cats may experience gastrointestinal issues, such as:vomiting,diarrhea,loss of appetite drooling.
Other Possible Side Effects:fever,fatigue,muscle twitching or weakness,nystagmus (involuntary eye movement),difficulty maintaining balance or walking,changes in behavior.
Clinical Pharmacology:
Ronidazole works by interfering with the DNA and other essential components of protozoa, particularly Tritrichomonas foetus (TTF), which is a protozoan parasite responsible for causing infections in animals, notably in cats.
Inhibition of DNA Synthesis: Ronidazole is a nitroimidazole compound, and once it enters the body, it undergoes a chemical reduction process. The reduced form of Ronidazole interacts with the DNA of the protozoa, disrupting its structure and inhibiting the synthesis of DNA. This interference hampers the ability of the protozoa to replicate and proliferate.
Production of Reactive Oxygen Species (ROS): Ronidazole also induces the production of reactive oxygen species within the cells of the protozoa. Reactive oxygen species are chemically reactive molecules containing oxygen that can cause damage to cellular structures and biomolecules. The increased oxidative stress contributes to the drug's effectiveness in killing or suppressing the protozoan parasites.
Metabolic Disruption: Ronidazole interferes with the energy metabolism of the protozoa. It disrupts key metabolic pathways, affecting the production of ATP (adenosine triphosphate), which is essential for cellular energy. This disruption further impairs the ability of the protozoa to function and survive.
Storage Information:
Do not store above 30 ℃.
Generic medication and its counterpart to have the same active ingredients, strength, quality, route of administration, and safety standards.All of our products are produced in GMP factories, Your pet’s health is our top priority.
This summary contains important information about Ronidazole. You should read this information before you start giving your pet Ronidazole and review it each time the prescription is refilled as there may be new information. This sheet is provided only as a summary and does not take the place of instructions from your veterinarian. Talk with your veterinarian if you do not understand any of this information or if you want to know more about Ronidazole.
What is Ronidazole?
Ronidazole is a medication used to treat protozoan infections in animals, particularly in cats. It is known for its effectiveness against Tritrichomonas foetus (TTF), a protozoan parasite that can cause severe diarrhea in cats. Ronidazole belongs to the nitroimidazole class of drugs and works by inhibiting the growth and reproduction of these protozoa.
What are the indications for Ronidazole?
Ronidazole is primarily indicated for the treatment of infections caused by certain protozoa, particularly Tritrichomonas foetus (TTF).
Here are the main indications for Ronidazole:
Tritrichomonas foetus Infections in Cats: Ronidazole is commonly used to treat Tritrichomonas foetus infections in cats. TTF is a protozoan parasite that can infect the large intestine, leading to chronic diarrhea in affected cats. This condition is more common in young cats and can be challenging to manage without appropriate treatment.
Tritrichomonas foetus Infections in Other Animals: Ronidazole may also be used to treat Tritrichomonas foetus infections in other animals, although its primary use and efficacy are well-documented in feline medicine.
What are the side effects of Ronidazole?
Ronidazole, like any medication, can potentially cause side effects. It's essential to monitor your pet closely during treatment, and if you observe any unusual signs or behaviors, contact your veterinarian promptly. Here are some potential side effects associated with Ronidazole use in cats.
Neurological Effects: Ronidazole can affect the nervous system, and signs may include:
Disorientation
Incoordination
Head tilting
Tremors
Seizures
Gastrointestinal Distress: Some cats may experience gastrointestinal issues, such as:
Vomiting
Diarrhea
Loss of appetite
Drooling
Other Possible Side Effects:
Fever
Fatigue
Muscle twitching or weakness
Nystagmus (involuntary eye movement)
Difficulty maintaining balance or walking
Changes in behavior
What drug interactions should be noted when using Ronidazole?
Ronidazole may interact with other medications, and it's crucial to be aware of potential drug interactions to ensure the safety and efficacy of the treatment. Here are some points to consider regarding drug interactions with Ronidazole:
Warfarin (Anticoagulant): Ronidazole may enhance the anticoagulant effects of warfarin. Caution and monitoring are advised when these drugs are used together.
Cimetidine (and other CYP3A4 Inhibitors): Cimetidine, an H2-receptor antagonist, may inhibit the metabolism of Ronidazole, potentially leading to increased levels of Ronidazole in the body. Other drugs that inhibit CYP3A4 should be used with caution.
Disulfiram (Antabuse): Ronidazole and disulfiram both inhibit aldehyde dehydrogenase. Concurrent use of these drugs may increase the risk of neurological side effects. The combination should be avoided.
Phenytoin and Other Anticonvulsants: Ronidazole may increase the serum concentration of phenytoin and other anticonvulsants, potentially leading to toxicity. Monitoring and dosage adjustments may be necessary.
Lithium: Ronidazole may increase the serum concentration of lithium, which could lead to lithium toxicity. Monitoring of lithium levels is recommended if used concomitantly.
Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking
What if I miss giving my pet the medication?
If you miss a dose, give it when you remember, but if it is close to the time for the next dose, skip the dose you missed and give it at the next scheduled time, and return to the regular dosing schedule. If you are giving this medication once daily and it is within 12 hours of the next dose, skip the missed dose and wait for the next scheduled time.Never give your pet two doses at once or give extra doses.
Are there any risk factors for this medication?
Do not use Ronidazole in pets that are allergic to it or other nitroimidazoles such as metronidazole. Dogs given this medication long term (for 2 years) had signs of testicular toxicity. It should be used cautiously in pets with seizures and very cautiously in pregnant animals; the benefits should outweigh the risks. If use in lactating animals is needed, use a milk replacer.
This medication is potentially carcinogenic to humans as it has been shown to cause cancer in mice, and has been shown to increase the rate of certain cancers in rats. As a precaution, wear gloves when administering this medication.
Is there any monitoring that needs to be done with this medication?
There is no specific monitoring that needs to be done while your pet is taking this medication. Your veterinarian may monitor your pet to be sure that the medication is working. Monitor your pet for serious side effects. Your veterinarian may check a polymerase chain reaction (PCR) test for the parasite although this test is not always accurate.
What should I do in case of emergency?
If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.